To controlforceaccurately under a wide range of behavioral conditions, the central nervous system would either require a detailed, continuously updated representation of the state of each muscle (and the load against which each is acting) or else force feedback with sufficient gain to cope with variations in the properties of the muscles and loads. The evidence for force feedback with adequate gain or for an appropriate central representation is not sufficient to conclude that force is the major controlled variable in (...) normal limb movements.Morton's hypothesis, thatlengthis controlled by a follow-up servo, has a number of difficulties related to the delays, gains, variability, and specificity in feedback pathways comprising potential servo loops. However, experimental evidence is consistent with these pathways providing servo assistance for some movements produced by coactivation of α- and static γ-motoneurons. Dynamic γ-motoneurons may provide an additional input for adaptive control of different types of movements.The idea that feedback is used to compensate for changes in musclestiffnesshas received experimental support under static postural conditions. However, reflexes tend to increase rather than decrease the range of variation in muscle stiffness during some cyclic movements. Theoretical problems associated with the regulation of stiffness are also discussed. The possibilities of separate control systems forvelocityorviscosityare considered, but the evidence is either negative or lacking. I conclude that different physical variables can be controlled depending on the type of limb movement required. The concept of stiffness regulation is also useful under some conditions, but should probably be extended to the regulation of the visco-elastic properties (i.e., the mechanical impedance) of a muscle or joint. (shrink)

One area in which the moral philosopher might say something useful for the thinking of economists is that of welfare economics – not by improving formalizations or criticizing proofs as to conditions necessary or sufficient for an optimum situation, much less by suggesting what particular state of society would be optimal. Rather, he can do this by pointing out some distinctions, by suggesting how some terms used by economists can profitably be defined, and by questioning some assumptions which seem to (...) lie behind the thinking of some economists. The following discussion is aimed along these lines. The main goal of the argument will be to produce helpful definitions of “increase the welfare of an individual” and “increase social welfare.”. (shrink)

E.R. Dodds’ 1959 edition of Plato’s Gorgias is a conventional treatment of this dialogue, aimed at audiences interested in close study of the text. Dodds himself regretted this outcome. He felt he had lost sight of an earlier goal, formulated at a time of political turmoil on the eve of WorldWar II, of using the Gorgias to bring out ‘both the resemblance and the difference between Plato’s situation and that of the intellectual today’. The present paper attempts to reconstruct that (...) goal, as it survives residually in his edition, surfaces in his The Greeks and the Irrational, and appears in some writings from the 1930s, particularly in unpublished lectures. Dodds did frequently juxtapose ancient and modern conceptions of the intellectual, and in a way that cast Plato in a positive light, as someone politically engaged and self-critical, and acutely sensitive, as Dodds himself was, to the political implications of social psychology. (shrink)

In their 2008 paper, Persson and Savulescu suggest that for moral bioenhancement (MBE) to be effective at eliminating the danger of ‘ultimate harm’ the intervention would need to be compulsory. This is because those most in need of MBE would be least likely to undergo the intervention voluntarily. By drawing on concepts and theories from epidemiology, this paper will suggest that MBE may not need to be universal and compulsory to be effective at significantly improving the collective moral standing of (...) a human populace and reducing the threat of ultimate harm. It will identify similarities between the mechanisms that allow biological contagions (such as a virus) and behaviours (such as those concerned with ethical and unethical actions) to develop, spread, and be reinforced within a population. It will then go onto suggest that, just as with the epidemiological principle of herd immunity, if enough people underwent MBE to reach a minimum threshold then the incidence and spread of immoral behaviours could be significantly reduced, even in those who have not received MBE. (shrink)

It is the aim of this paper to examine certain aspects of a point of view which has attracted much attention in physical methodology. This is the standpoint known as operationalism. We wish to discuss its significance in the construction and interpretation of physical theories.The essential meaning of operationalism in physics is that physical concepts should be defined in terms of actual physical operations. On this view there is no meaning to a concept unless it represents an operation which can (...) be performed in the laboratory. Thus the term “pressure of a gas” signifies nothing until an operation is described which constitutes the measurement of pressure. When one thinks of pressure one must think. of some actual apparatus, such as, for example, some glass and rubber tubing and some mercury and certain operations performed using these until finally one gets a pointer reading which one calls the pressure of the gas. The same stand is taken with respect to length, time, velocity, acceleration, temperature, etc. (shrink)

In the paper “Translational Neuroethics: A Vision for a More Integrated, Inclusive, and Impactful Field,” Wexler and Sullivan provide an insightful analysis of challenges within the field and how t...

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)

This study examines whether scenic beauty judgments based upon photographs of landscapes are similar to scenic beauty judgments based upon on-site experiences of landscapes. Two concerns are emphasized: a concern about the threat to the ecological validity of photo-based assessments caused by differences between on-site and photo-based contexts and a concern that the individual rater, rather than the group average, is the more appropriate unit of analysis for tests of validity of photo-based assessments. On-site scenic beauty assessments were collected from (...) day hikers. These data were compared to photo-based scenic beauty assessments collected from the same persons three months and nine months after their on-site experience. Approximately 38% of participants had insignificant correlations between their on-site and photo-based scenic beauty ratings. These and other results suggest that the validity of photo-based scenic beauty assessments is in doubt, at least for the situation studied here. Moreover, the results suggest that the difference between persons' on-site and photo-based ratings can be explained, in part, by contextual factors such as the mood, meaning, and novelty that differentiate photo-based from on-site landscape experiences. Group averaged on-site and photo-based assessments, however, were very similar, suggesting caution may be in order for studies interpreting summary measures. (shrink)

Despite All Critique (2014) -- World Politics and Western Reason (1980) -- The Doubled Outsides of the Modern International (2005) -- The Subject of Security (1995) -- The Protection of Nature and the Nature of Protection (2005) -- Social Movements/World Politics (1994) -- Europe is Not Where It is Supposed to Be (2000) -- They Seek it Here, They Seek it There : Looking for Politics in Clayoquot Sound (2003) -- Violence, Modernity, Silence : From Weber to International Relations (1993) (...) -- Hobbes, Origins, Limits (2011) -- War, Terror, Judgement (2002) -- International, Imperial, Exceptional (2005) -- Which Democracy for Which Demos? (2013) -- The Political Theory of Boundaries and the Boundaries of Political Theory : Interview With Raia Prokhovnik (2012). (shrink)

William Frankena has several times discussed, in his usual cautious and judicious manner, a contrast between two types of normative ethics: an ethics of “duty” and an ethics of “virtue.” Without claiming that actual philosophers have been pure exemplars of either type, he has tried to give a clear statement of these two possible and contrasting types of theory, and to expose their problems. His final view seems to be that a complete normative theory will combine elements of both, but (...) that an ethics of “duty” in some sense is more fundamental. Plato and Aristotle seem to differ from him in being more sympathetic to a “virtue-ethics.” Leslie Stephen went so far as to claim that satisfactory principles of duty cannot even be stated and that a moral philosopher spends his time better formulating an ideal of virtue. James Martineau is another classical figure more sympathetic to “virtue-ethics.”. (shrink)

An examination of our preconceptions about desire, together with a comparison of these with the available empirical evidence, leads to a theory in which desire is characterized as a cognitive phenomenon which is heavily influenced by social learning. Following an introductory outline, the second section clarifies what exactly is at issue in attempting to reduce conation to cognition. Section 3 assesses the conditions required for knowledge of our own desires, and this concern is extended in 4 to an appraisal of (...) the role played by self-knowledge in the process of change through psychotherapy. The concluding section argues that the Social-cognitive Theory of Desire is compatible with contemporary neo-Dar-winian views of evolution. (shrink)

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In order to explain the idea that sacrifice involves voluntary diminution of the agent’s well-being, “well-being” must be explained. The thesis that an agent’s well-being just consists in the occurrence of events wanted is rejected. Overvold replaces it by the view that the motivating desires involve the existence of the agent, alive, at the time of their satisfaction. This view seems counterintuitive. The whole desire-satisfaction theory is to be rejected partly because we dont’t think an event worthwile if it is (...) not liked when it occurs, and partly because the theory cannot give a sensible account of what is good for an individual when his desires change. A more satisfactory view is that the goodness of an event for a person is fixed by his total gratifications as a result of its occurrence, provided they would occur if the person were fully informed about facts knowledge of which would change them if it existed. But self-sacrifice seems to involve not only voluntary diminution of well-being in this sense, but belief that the action is taken for the benefit of someone else. Overvold’s view leaves open the possibility that acting morally is never contrary to self-interest, if one of the agent’s major interests is that he act morally. This is an ingenious suggestion, but seems a bit counterintuitive. (shrink)